A large study by researchers at Columbia University Mailman School of Public Health and the Norwegian National Institute of Public Health has identified molecular signatures of gestational inflammation linked to the risk of developing autism spectrum disorder (ASD).
In earlier studies, the researchers linked ASD risk to prenatal exposure to maternal fever, and to influenza infection and herpesvirus type 2 infection — two of many potential triggers for maternal inflammation and ASD.
These findings, which provide insights into abnormal brain development, could eventually lead to a test to screen for ASD at birth. The study is published in the journal Molecular Psychiatry.
The new research aligns with growing evidence that the risk of ASD is increased by fetal exposure to inflammation.
In the new study, researchers analyzed the presence of 60 molecular markers of immune response, including cytokines and growth factors.
Blood samples were collected during pregnancy (maternal mid-gestational blood sample) and at birth (cord blood) from 957 children, roughly half of whom were later diagnosed with ASD.
The study linked ASD risk to groupings of inflammation-related molecules, with different groupings seen in boys versus girls. Among the most predictive molecules were interleukins like IL1RA and IL4.
Four molecules thought to be involved in fetal brain development were also linked to ASD risk in both sexes: TNFα, Serpin E1, VCAM1, and IL1β. Biomarkers collected at birth were only slightly less predictive than those collected during pregnancy.
«Our research suggests a period of vulnerability during gestation when inflammation can interfere with central nervous system development,» says first author Xiaoyu (Jason) Che, PhD, assistant professor of biostatistics in the Center for Infection and Immunity at Columbia Mailman School.
«We found immune signatures in mid-pregnancy blood samples from mothers and in umbilical cord blood from children later diagnosed with autism that correlate with responses to infection, and molecules important for the development of the brain and its blood supply,» says study co-first author Mady Hornig, MD, associate professor of epidemiology at Columbia Mailman School.
«This work illustrates the unique power of prospective cohorts for elucidating the roots of disease,» says corresponding author, Ezra Susser, professor of epidemiology and psychiatry.
«This paper is the culmination of more than 20 years of data and sample collection and analysis in collaboration with our colleagues in the Norwegian Institute of Public Health.
Our future research will focus on finding the triggers for inflammation and links between those triggers and genetic susceptibility,» said W. Ian Lipkin, John Snow Professor of Epidemiology and professor of neurology and pathology.
About the Autism Birth Cohort (ABC) Study
The Autism Birth Cohort (ABC) study was conducted within a large Norwegian cohort of more than 100,000 children who have been followed since before their birth.
ABC is a joint effort of the Norwegian National Institute of Public Health (NIPH) and Columbia Mailman School investigators, overseen by a Steering Committee of four people:
Camilla Stoltenberg and Per Magnus in Norway; and Ian Lipkin and Ezra Susser at Columbia. «The ABC study is unique for the scope, depth, and breadth of both biological and social data on ASD,» notes Susser.
The research was supported by the National Institutes of Health (grants NS047537, NS086122), Jane Botsford Johnson Foundation, Korein Foundation, Simons Foundation Autism Research Initiative, the Norwegian Ministry of Health and Care Services, the Norwegian Ministry of Education and Research, and Research Council of Norway (grants 189457, 190694, 196452).
The funders had no role in study design, data collection, and interpretation, or the decision to submit the work for publication. None of the authors reported biomedical financial interests or potential conflicts of interest.
Source:https://www.sciencedaily.com/releases/2022/01/220105174106.htm
I went over this website and I think you have a lot of wonderful info, saved to bookmarks (:.
Keep functioning ,impressive job!
This is the right website for anyone who wants to understand this topic. You understand so much its almost hard to argue with you (not that I really would want toÖHaHa). You certainly put a brand new spin on a subject that has been discussed for many years. Wonderful stuff, just wonderful! This is the right website for anyone who wants to understand this topic. You understand so much its almost hard to argue with you (not that I really would want toÖHaHa). You certainly put a brand new spin on a subject that has been discussed for many years. Wonderful stuff, just wonderful! נערות ליווי ברמלה
An impressive share, I just given this onto a colleague who was doing a little analysis on this. And he in fact bought me breakfast because I found it for him.. smile. So let me reword that: Thnx for the treat! But yeah Thnkx for spending the time to discuss this, I feel strongly about it and love reading more on this topic. If possible, as you become expertise, would you mind updating your blog with more details? It is highly helpful for me. Big thumb up for this blog post!
I am really impressed with your writing skills and also with the layout on your blog. Is this a paid theme or did you modify it yourself? Anyway keep up the excellent quality writing, it is rare to see a great blog like this one today..
I was excited to discover this website. I want to to thank you for your time for this wonderful read!! I definitely liked every part of it and i also have you book-marked to look at new things on your website.
Nice post i like it 100 %. I learn something new and challenging on sites I stumbleupon on a daily basis. Its always helpful to read through articles from other writers and use something from their web sites.
Thank you for every other informative site. Where else could I get that kind of information written in such an ideal approach? I’ve a mission that I’m simply now working on, and I have been on the look out for such information.
Absolutely written written content, Really enjoyed reading through.
Hiya, I’m really glad I’ve found this info. Nowadays bloggers publish only about gossips and web and this is actually irritating. A good website with exciting content, that is what I need. Thanks for keeping this web-site, I’ll be visiting it. Do you do newsletters? Cant find it.
Sweet internet site, super layout, rattling clean and employ friendly.
Hi there, i read your blog occasionally and i own a similar one and i was just wondering if you get a lot of spam comments? If so how do you prevent it, any plugin or anything you can advise? I get so much lately it’s driving me mad so any support is very much appreciated.
Very interesting topic, appreciate it for putting up. «Ok. Sex is fine. Sex is good. Sex is GREAT Okay, okay, we need men for sex… Do we need so many» by Sybil Adelman.
Virtually all of the things you point out happens to be astonishingly legitimate and it makes me ponder the reason why I hadn’t looked at this in this light before. This particular piece really did switch the light on for me personally as far as this specific subject goes. But there is one particular position I am not too comfy with so while I make an effort to reconcile that with the main idea of the point, permit me observe exactly what all the rest of your visitors have to point out.Nicely done.
I have been browsing on-line more than three hours lately, yet I by no means discovered any attention-grabbing article like yours. It is beautiful worth sufficient for me. Personally, if all web owners and bloggers made just right content material as you did, the web will probably be a lot more helpful than ever before.
There are some interesting deadlines on this article however I don’t know if I see all of them heart to heart. There may be some validity but I’ll take hold opinion till I look into it further. Good article , thanks and we want more! Added to FeedBurner as effectively
Very interesting details you have noted, thankyou for posting. «History is a cyclic poem written by Time upon the memories of man.» by Percy Bysshe Shelley.
Oh my goodness! an incredible article dude. Thank you Nonetheless I am experiencing difficulty with ur rss . Don’t know why Unable to subscribe to it. Is there anyone getting similar rss downside? Anyone who knows kindly respond. Thnkx
It is the best time to make a few plans for the longer term and it’s time to be happy. I’ve learn this submit and if I could I want to counsel you some fascinating issues or tips. Maybe you could write subsequent articles relating to this article. I want to read more things about it!
Thanks for another informative website. Where else could I get that type of information written in such an ideal way? I’ve a project that I’m just now working on, and I’ve been on the look out for such info.
Very interesting topic, thanks for posting.
I would like to thnkx for the efforts you have put in writing this blog. I am hoping the same high-grade blog post from you in the upcoming as well. In fact your creative writing abilities has inspired me to get my own blog now. Really the blogging is spreading its wings quickly. Your write up is a good example of it.
After study a few of the blog posts on your website now, and I truly like your way of blogging. I bookmarked it to my bookmark website list and will be checking back soon. Pls check out my web site as well and let me know what you think.
I’m extremely impressed with your writing skills as well as with the layout on your weblog. Is this a paid theme or did you modify it yourself? Either way keep up the excellent quality writing, it’s rare to see a nice blog like this one nowadays..