Quantitative Subcellular Proteomics in Children and Adults with Idiopathic Autism

S. Hossein Fatemi, MD, PhD
Timothy Griffin, PhD
University of Minnesota

Autism is a severe neurodevelopmental disorder with a rising prevalence of 18.5 per 1000 (1 in 54) in the United States.

There have been few studies of the proteome of brains of individuals with autism.

Our long-range goal is to identify biomarkers for autism by combining subcellular fractionation and proteomics.

The objective of the current application is to determine the subcellular proteomes of individuals with autism vs. controls.

The central hypothesis is that proteomics will identify unique subcellular proteomes in subjects with autism vs. controls and that there will be differences related to age and brain region.

The rationale for the current proposal is that there is a dearth of brain subcellular proteomic studies related to autism.

The project consists of the following specific aim:

Determine the proteome of the synaptic fraction in superior frontal cortex (BA9) and cerebellar vermis of subjects with idiopathic autism vs. healthy controls.

Our work is innovative because these studies will provide important information about protein dysregulation in autism.

Source: https://www.autism.org/ari-funded-research-studies-2020/

HTTPS://WWW.MONKEYSELECTION.COM

Esta entrada fue publicada en AUTISMO, INVESTIGACION. Guarda el enlace permanente.

6 respuestas a Quantitative Subcellular Proteomics in Children and Adults with Idiopathic Autism

  1. froleprotrem dijo:

    Wohh just what I was searching for, thanks for putting up.

  2. froleprotrem dijo:

    Hey! I’m at work surfing around your blog from my new apple iphone! Just wanted to say I love reading through your blog and look forward to all your posts! Carry on the fantastic work!

  3. froleprotrem dijo:

    Have you ever thought about publishing an e-book or guest authoring on other websites? I have a blog centered on the same topics you discuss and would really like to have you share some stories/information. I know my visitors would enjoy your work. If you are even remotely interested, feel free to send me an email.

  4. Ophelia dijo:

    Hi! I could have sworn I’ve been to your blog
    before but after going through some of the articles I
    realized it’s new to me. Anyways, I’m definitely delighted I stumbled upon it and I’ll be bookmarking it and checking back regularly!

  5. Sylvester dijo:

    It is in point of fact a nice and useful piece of information. I am satisfied that you just shared
    this helpful info with us. Please stay us informed like this.

    Thanks for sharing.

  6. Raymond dijo:

    What’s up, all is going well here and ofcourse every one is sharing information, that’s truly fine, keep up writing.

Deja una respuesta

Tu dirección de correo electrónico no será publicada.