Advances in Genetics

  1. Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. Bai D, Yip, BHK, Windham, GC, et al. JAMA Psychiatry. 2019 Jul 17.

2. Identification of common genetic risk variants for autism spectrum disorder. Grove J, Ripke, S, Als, TD, et al. Nature Genetics. 2019 Mar;51(3):431-444.

3. Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks. Ruzzo EK, Pérez-Cano L, Jung JY, et al. Cell. 2019 Aug 8;178(4):850-866.e26. 

“The first study examined genetic and environmental factors contributing to autism in Denmark, Finland, Sweden, Western Australia and Israel.

Estimates of additive genetic risk ranged from 51 percent in Finland to 87 percent in Israel and estimates of environmental risk ranged from 13 percent in Israel to 35 percent in Finland,” said Ed Cook, Earl M. Bane Professor of Psychiatry, Director of the Program for Neurodevelopmental Disorders and Director of the Division of Child and Adolescent Psychiatry at University of Illinois-Chicago College of Medicine.

The second study, by Grove and colleagues, reported the largest genetic study to date, looking for gene changes that are linked with autism. It included more than 18,000 subjects with autism and more than 27,000 control subjects.

“Five statistically significant loci were identified and relationships were found between polygenic scores for ASD and several other conditions, including ADHD and major depression,” Cook said.

Finally, Ruzzo and colleagues used a dataset featuring more detailed genetic information via whole genome sequencing looking for new genes that may contribute to autism.

They performed WGS on samples from the Autism Genetic Research Exchange, supported by Autism Speaks, of people with two or more affected siblings with autism spectrum disorder. “They also contrasted the biological effects of genes found in these multiplex families to genes implicated by findings in families with only one child with ASD,” Cook said.

Taken together, these three studies represent a shift toward larger datasets, whether through collaboration or through more detailed sequencing available with more sophisticated genetic tests like whole genome sequencing.
“ASD risk remains complex and multifactorial,” Cook said.


Esta entrada fue publicada en AUTISMO, INVESTIGACION. Guarda el enlace permanente.

31 respuestas a Advances in Genetics

  1. zortilonrel dijo:

    I do love the way you have framed this particular situation and it does offer us a lot of fodder for thought. On the other hand, coming from just what I have experienced, I simply trust as the feed-back stack on that folks stay on point and don’t get started on a tirade involving the news of the day. Yet, thank you for this fantastic piece and whilst I can not go along with this in totality, I value the standpoint.

  2. When I initially commented I clicked the «Notify me when new comments are added» checkbox and now each time a comment is added I get several emails with the same comment. Is there any way you can remove me from that service? Thanks a lot!

  3. zortilonrel dijo:

    As I web site possessor I believe the content material here is rattling great , appreciate it for your hard work. You should keep it up forever! Good Luck.

  4. froleprotrem dijo:

    Thank you a lot for providing individuals with an extremely breathtaking chance to read critical reviews from this website. It can be very terrific and as well , stuffed with a good time for me personally and my office colleagues to search your web site no less than 3 times per week to see the fresh guidance you will have. Of course, I’m also usually happy with the breathtaking inspiring ideas you give. Selected 1 points on this page are indeed the very best we’ve ever had.

  5. Hello! I just would like to give a huge thumbs up for the great info you have here on this post. I will be coming back to your blog for more soon.

  6. I don’t know if it’s just me or if perhaps everybody else encountering problems with
    your website. It appears as if some of the written text in your
    content are running off the screen. Can somebody else please comment and let
    me know if this is happening to them as well? This could
    be a issue with my internet browser because I’ve had this happen previously.

    Kudos 0mniartist asmr

  7. Hey There. I found your weblog the usage of msn.
    That is a very smartly written article. I’ll make sure
    to bookmark it and come back to
    your helpful info. Thank you for the post. I will definitely comeback.
    0mniartist asmr

  8. This site was… how do you say it? Relevant!! Finally I have found something which helped me.
    Thank you! asmr 0mniartist

  9. dijo:

    I’m extremely impressed with your writing talents and also
    with the format for your blog. Is that this a paid theme or did you customize it your self?
    Anyway keep up the excellent quality writing, it is rare to look a nice weblog like this
    one today.. 0mniartist asmr

  10. that gamefly dijo:

    If you desire to take a great deal from this piece of
    writing then you have to apply such strategies to your won web site.

  11. is asmr dijo:

    Useful information. Lucky me I found your web site by accident, and I’m shocked why this accident didn’t took place in advance!
    I bookmarked it.

  12. when asmr dijo:

    I know this site offers quality dependent posts and
    extra information, is there any other web
    site which gives such stuff in quality?

  13. asmr this dijo:

    I used to be able to find good information from your blog posts.

  14. dijo:

    You could definitely see your enthusiasm within the article you write.
    The arena hopes for even more passionate writers such as you who
    aren’t afraid to say how they believe. Always follow your heart.

  15. a asmr dijo:

    When I originally commented I clicked the «Notify me when new comments are added» checkbox and
    now each time a comment is added I get several emails with the same comment.
    Is there any way you can remove me from that service?

    Thank you!

  16. scoliosis
    The other day, while I was at work, my sister stole my
    apple ipad and tested to see if it can survive
    a 30 foot drop, just so she can be a youtube sensation. My apple
    ipad is now broken and she has 83 views. I know this is totally off
    topic but I had to share it with someone! scoliosis

  17. in asmr dijo:

    I think this is one of the most important information for me.
    And i’m satisfied reading your article. However
    wanna remark on few general things, The web site taste is perfect, the articles is really
    great : D. Just right process, cheers

  18. This is a topic which is near to my heart… Thank you! Where
    are your contact details though?

  19. Saved as a favorite, I really like your website!

  20. zortilo nrel dijo:

    Way cool, some valid points! I appreciate you making this article available, the rest of the site is also high quality. Have a fun.

  21. Beth dijo:

    Hey are using WordPress for your site platform?
    I’m new to the blog world but I’m trying to get started and set up my own. Do you
    need any html coding knowledge to make your own blog?
    Any help would be really appreciated!

  22. Thanks for sharing, this is a fantastic article.Much thanks again. Fantastic.

  23. Shoshana dijo:

    This is very interesting, You’re a very skilled blogger.
    I have joined your rss feed and look forward to seeking more of your
    great post. Also, I have shared your website in my social networks!

  24. dijo:

    A person essentially help to make critically articles I would state.

    This is the very first time I frequented your web page and to this
    point? I amazed with the analysis you made to create
    this particular put up incredible. Excellent job!

  25. dijo:

    You are so awesome! I don’t think I’ve truly read something like that
    before. So good to discover somebody with a few unique thoughts
    on this subject. Seriously.. many thanks for
    starting this up. This site is one thing that is needed on the web, someone with a
    bit of originality!

  26. Archie dijo:

    My family members always say that I am killing my time here at net, but I know
    I am getting experience daily by reading thes pleasant articles.

  27. Barbra dijo:

    This website truly has all of the information and facts I
    wanted concerning this subject and didn’t know who to ask.

  28. Your means of telling all in this post is genuinely good, every one be able
    to easily be aware of it, Thanks a lot.

  29. dijo:

    At this moment I am going to do my breakfast, when having my breakfast coming again to read more news.

  30. dijo:

    Wow, that’s what I was seeking for, what a data! present here at this website, thanks admin of
    this web site.

  31. manhwaland dijo:

    I really liked your article.Thanks Again. Keep writing.

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *