Inherited Variations in Noncoding Sections of DNA Associated with Autism

A new study has identified an association between paternally-inherited rare structural variants in noncoding segments of genes and the development of autism spectrum disorder (ASD)The study, funded in part by the National Institute of Mental Health (NIMH) and published in Science, adds to a growing body of research describing genetic contributors to ASD.

ASD is a developmental disorder that affects communication and behavior. Researchers have identified a number of genes associated with the development of ASD.

Many studies have focused on examining the inheritance of, or mutations in, portions of genes that code for the creation of proteins or other molecular products. But these new findings suggest that rare, inherited structural differences in the noncoding portions of genes also contribute to ASD.

“Gene sequences represent only two percent of the genome.” said Jonathan Sebat, Ph.D., of University of California San Diego School of Medicine (UCSD) and the Beyster Center for Genomics of Psychiatric Diseases.

“The next challenge is to identify ASD risk variants affecting genetic regulatory elements. Examining these elements will help us understand the genetic components that contribute to the development of ASD, and symptoms seen in people with ASD.”

The researchers examined the contribution of structural variants in noncoding regions of DNA called cis-regulatory elements (CRE-SVs) to ASD. These elements control the expression of genes.

The researchers sequenced the genomes of 829 families, which included 880 individuals with ASD, 630 individuals without ASD, and their parents. Participants with genetic mutations that are already well-established risk factors for ASD were not included in this study.

In this way, the researchers were able to focus on identifying noncoding inherited genetic variants that might be associated with ASD.

The researchers identified structural variations in coding and noncoding portions of DNA, and they examined the inheritance of these genetic elements from parents to their offspring.

Their research revealed deletions in protein-coding areas of genes were transmitted more often from parents to offspring with autism than from parents to offspring without autism.

They also found that CRE-SVs were transmitted more often from fathers to offspring with autism then from fathers to offspring without autism. Inheritance of maternal CRE-SVs were not associated with ASD in offspring.

Although the researchers found spontaneous (i.e., non-inherited) genetic mutations in the coding regions of offspring’s DNA, no spontaneous CRE-SV mutations in cases were found.

These findings were successfully replicated in a preregistered follow-up experiment examining the genomes of over 6,000 people. Based on this experiment, the authors estimate that:

  1. Rare inherited cis-regulatory components contribute in 0.77 percent of autism cases;
  2. Structural variants in coding regions contribute in 1.21 percent of autism cases;
  3. Additional inherited pathogenic variants contribute in 1.9 percent of autism cases; and,
  4. Spontaneous mutations to coding regions contribute in 5.1 percent of autism cases.

The paternal origin of CRE-SVs associated with autism contrasts with what would be expected based on simpler genetic models of autism which suggest that inherited genetic risk factors for autism originate predominantly from mothers.

“The paternal origin effect that we see for CRE-SVs suggests that the inherited genetic contribution from mothers and fathers may be qualitatively different,” said Dr. Sebat.

The findings also provide a demonstration of the usefulness of SV analysis for identifying and understanding the genetic regulatory elements that influence risk for ASD.

Data reported in the article are archived at the National Database for Autism Research (DOI:10.15154/1340302)

Esta entrada fue publicada en AUTISMO, DIVULGACIÓN. Guarda el enlace permanente.

8 respuestas a Inherited Variations in Noncoding Sections of DNA Associated with Autism

  1. berkey dijo:

    This design is wicked! You most certainly know how to keep a reader amused. Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Excellent job. I really enjoyed what you had to say, and more than that, how you presented it. Too cool!|

  2. zortilo nrel dijo:

    Aw, this was a really nice post. In concept I would like to put in writing like this additionally – taking time and precise effort to make an excellent article… however what can I say… I procrastinate alot and by no means seem to get something done.

  3. feed dijo:

    It’s very trouble-free to find out any topic on net as compared to textbooks, as I found this paragraph at this site.|

  4. thefeed dijo:

    What’s up to all, it’s genuinely a pleasant for me to pay a visit this site, it includes useful Information.|

  5. thefeed dijo:

    I got this site from my buddy who informed me regarding this web page and now this time I am browsing this web site and reading very informative posts at this time.|

  6. thefeed dijo:

    Hello, i think that i saw you visited my web site thus i got here to return the favor?.I’m trying to find issues to improve my site!I suppose its adequate to use some of your ideas!!|

  7. froleprotrem dijo:

    Thank you for the sensible critique. Me & my neighbor were just preparing to do some research about this. We got a grab a book from our area library but I think I learned more clear from this post. I’m very glad to see such magnificent info being shared freely out there.

  8. Attractive section of content. I just stumbled upon your site and in accession capital to assert that I acquire actually enjoyed account your blog posts. Anyway I’ll be subscribing to your feeds and even I achievement you access consistently fast.|

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *