Clinical Manifestations and the Intestinal Microbiome in Individuals on the Autism Spectrum with Inflammatory Bowel Diseases

Harland Winter, MD
Director, Pediatric IBD Program
Massachusetts General Hospital

Many individuals with an autism spectrum disorder (ASD) have comorbid conditions that impact not only on their quality of life, but also on longevity.

Deaths from comorbid gastrointestinal disorders in individuals with ASD are over 40 times higher than neurotypical peers.

Furthermore, unrecognized clinical presentations of underlying medical conditions may result in delayed diagnosis.

Specific aims:

(1) To characterize the clinical presentation, response to therapy and outcomes of individuals with ASD who have Crohn’s disease or ulcerative colitis;

(2) To describe the mucosal associated microbiome in individuals with ASD and Crohn’s disease/ulcerative colitis;

(3) To continue to develop the biorepository as a resource for investigators needing access to mucosal biopsies, serum, DNA,

RNA and stool from patients with and without ASD.



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